Skin changes can indicate more serious internal disease. I’m Erin White and THIS is a dailyRx Minute. While every body develops a rash from time to time, odd changes to the skin can also be a symptom of more serious health issues going on inside the body. A new rash that brings fever, joint pain or other unusual symptoms could be a sign of an internal problem. Certain muscle diseases and several different types of cancers have been known to cause skin changes that you should have checked out. To read the remaining skin irritation guidelines.